Anti-MOK Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q9UQ07

Core Product Specifications and Parameters

Biological Background: MOK Function and Localization

• Full name: MAPK/MAK/MRK overlapping kinase, also known as MOK protein kinase and Renal tumor antigen 1 (RAGE-1).
• Encoded by the MOK gene (RAGE, RAGE1), it functions as a serine/threonine-protein kinase.
• Phosphorylates several exogenous substrates and undergoes autophosphorylation; negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
• Localizes to the cytoplasm, cell projections including cilia, and nucleus.
• Expressed in heart, brain, lung, kidney, and pancreas; low in placenta, liver, skeletal muscle; detected in retina.
• Keywords: Alternative splicing, ATP-binding, Cilium, Kinase, Transferase, Phosphoprotein.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-230) of human MOK; consider this when working with epitope-tagged constructs or truncation mutants.
• For Western blot, a band around 48 kDa is expected; use positive control lysates from human, mouse, or rat tissues with known MOK expression, such as kidney or brain.
• For IHC-P, perform antigen retrieval and validate staining in tissues like kidney or retina with appropriate negative controls to confirm specificity.
• For ELISA, use the recombinant immunogen as a positive control to optimize coating and detection conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides IVD manufacturers, laboratories, and research institutes with one-stop access to raw materials, technical services, and consulting—covering every stage from concept to clinic. Our portfolio includes validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For rare or challenging targets like MOK, we offer custom sourcing solutions to accelerate your diagnostic development.