Anti-MKKS Rabbit Polyclonal Antibody for WB and ELISA - Q9NPJ1

Core Product Specifications and Parameters

Biological Background: Molecular chaperone MKKS Function and Localization

• Also known as Bardet-Biedl syndrome 6 protein (BBS6) and McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin, encoded by the MKKS gene.
• Functions as a probable molecular chaperone that assists protein folding upon ATP hydrolysis. Related references: PMID:20080638
• Plays a critical role in the assembly of the BBSome, a complex essential for ciliogenesis and ciliary transport. Related references: PMID:20080638
• May contribute to protein processing during limb, cardiac, and reproductive system development.
• Involved in cytokinesis, the final stage of cell division. Related references: PMID:28753627
• Localizes to the cytoplasm, cytoskeleton, centrosome, cytosol, and nucleus.
• Widely expressed across adult and fetal tissues.
• Linked to Bardet-Biedl syndrome and other ciliopathies; possesses an ATP-binding domain.

Experimental Guidance and Technical Tips

• For WB, the antibody may detect a band around 62 kDa, consistent with the predicted molecular weight of MKKS. Use appropriate positive controls, such as human cell lysates known to express MKKS.
• In ELISA applications, consider direct or sandwich formats, with careful optimization of coating and detection conditions.
• The immunogen corresponds to amino acids 221–570, which may yield reactivity against full-length MKKS and possibly truncated variants; verify specificity in the relevant sample system.
• Cross-reactivity has been observed with human samples; validation in other species is not provided and should be performed independently if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a premier one-stop partner for IVD raw material sourcing, supporting diagnostic manufacturers, labs, and research institutes with validated antibody pairs, monoclonal and polyclonal antibodies, bulk ancillary reagents, and custom rare-target procurement. This MKKS antibody enables research into molecular chaperones, ciliogenesis, and related disorders, with CamelBio’s robust supply chain ready to accelerate your diagnostic development from concept to clinic.