Anti-MESDC2 Polyclonal Antibody for WB and ELISA - Q14696

Core Product Specifications and Parameters

Biological Background: MESDC2 Function and Localization

• MESDC2, also known as LRP chaperone MESD, BOCA, or OI20, is encoded by the MESD gene (alternative symbols KIAA0081, MESDC2, MESDM) and may undergo alternative splicing.
• Functions as a chaperone specifically assisting the folding of beta-propeller/EGF modules within low-density lipoprotein receptor (LDLR) family members. Related references: PMID:15014448
• Acts as a modulator of the canonical Wnt signaling pathway by chaperoning the coreceptors LRP5 and LRP6 to the plasma membrane. Related references: PMID:17488095 PMID:23572575
• Essential for embryonic polarity specification, mesoderm induction, and neuromuscular junction (NMJ) formation through promoting cell-surface expression of LRP4.
• Localizes to the endoplasmic reticulum.
• Classified as a glycoprotein and linked to the disease osteogenesis imperfecta; implicated in Wnt signaling pathway.
• May regulate phagocytosis of apoptotic retinal pigment epithelium cells.

Experimental Guidance and Technical Tips

• The immunogen comprises nearly the full-length human MESDC2 protein (amino acids 1–234); consider that the polyclonal antibody may recognize conserved epitopes in mouse (cross-reactivity confirmed).
• For Western blotting, validate the antibody in human or mouse cell lysates and expect a band at approximately 26 kDa.
• For ELISA, the antibody can be tested as a capture or detection reagent; optimal dilutions and conditions should be empirically determined.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated partner for diagnostic manufacturers and life science researchers, offering one-stop access to validated IVD raw materials. This anti-MESDC2 polyclonal antibody exemplifies our portfolio supporting LDLR chaperone and Wnt pathway studies. From specialty antibodies and bulk ancillary reagents to rare-target sourcing, CamelBio streamlines your journey from concept to clinic.