Anti-MEIS3 Polyclonal Antibody for Western Blot and ELISA - Q99687

Core Product Specifications and Parameters

Biological Background: MEIS3 Function and Localization

• MEIS3, also known as Meis1-related protein 2 (MRG2), is a homeobox-containing transcriptional regulator.
• It directly modulates PDPK1 expression, thereby promoting the survival of pancreatic beta-cells.
• MEIS3 also regulates the expression of NDFIP1, BNIP3, and CCNG1, highlighting its role in gene regulatory networks.
• The protein localizes exclusively to the nucleus, consistent with its function as a transcription factor.
• MEIS3 belongs to the TALE/MEIS family of homeodomain proteins, characterized by a three-amino-acid loop extension (TALE) in the homeodomain.
• Alternative splicing of MEIS3 generates multiple isoforms, potentially with distinct functional properties.
• Keywords associated with MEIS3 include alternative splicing, DNA-binding, homeobox, nucleus, and reference proteome, reflecting its annotated features.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 325-375 near the C-terminus of human MEIS3; consider verifying specificity in relevant cell types via knockdown or overexpression.
• For Western blot, the predicted molecular weight is approximately 41 kDa; use suitable gel percentage and transfer conditions.
• As cross-reactivity is reported for human, mouse, and rat, validate the antibody in the appropriate species sample context.
• For ELISA applications, a recombinant MEIS3 protein standard may assist in assay optimization and quantification.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with streamlined access to IVD raw materials, from antibody pairs to bulk ancillary reagents. This anti-MEIS3 polyclonal antibody supports investigations into transcriptional regulation and pancreatic biology. We offer one-stop sourcing for validated mono- and polyclonal antibodies, technical consultation, and supply-chain management to accelerate your projects from concept to clinic.