Anti-MATN3 Rabbit Polyclonal Antibody for WB, ELISA - O15232

Core Product Specifications and Parameters

Biological Background: Matrilin-3 Function and Localization

• Matrilin-3, encoded by the MATN3 gene, is a major component of the extracellular matrix of cartilage.
• It plays a role in the formation of extracellular filamentous networks, contributing to cartilage structure and integrity.
• Expression is restricted to cartilaginous tissues, including vertebrae, ribs, and shoulders.
• The protein is secreted from cells to function in the extracellular space.
• It contains structural motifs such as coiled-coil domains, EGF-like domains, and disulfide bonds that mediate protein interactions.
• Post-translational modifications include phosphorylation and methylation, which may regulate its activity.
• Alternative splicing produces multiple isoforms, potentially with distinct functions.
• Mutations in MATN3 are associated with skeletal diseases such as multiple epiphyseal dysplasia (EDM5) and spondyloepimetaphyseal dysplasia (SEMDBCD), highlighting its importance in skeletal development.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (amino acids 277-486), which may be suitable for detecting full-length MATN3 under denaturing Western blot conditions.
• For ELISA applications, consider pairing with a capture antibody if developing a sandwich assay; validate performance in the relevant sample system.
• Cross-reactivity with mouse and rat allows for translational studies in rodent cartilage models.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-MATN3 polyclonal antibody supports cartilage and skeletal disease research. Explore our portfolio for validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing.