Anti-MARVELD2 (Tricellulin) Rabbit Polyclonal Antibody for WB, ELISA - Q8N4S9

Core Product Specifications and Parameters

Biological Background: MARVELD2 Function and Localization

• MARVELD2, also known as tricellulin, is a MARVEL domain-containing protein encoded by the MARVELD2 gene (Synonyms: TRIC, DFNB49, MARVD2, MRVLDC2).
• It plays a key role in the formation of tricellular tight junctions and the maintenance of epithelial barriers (By similarity).
• Required for normal hearing; it facilitates the separation of endolymphatic and perilymphatic spaces in the organ of Corti and supports hair cell survival [PMID:17186462] Related references: PMID:17186462
• Subcellularly, MARVELD2 localizes to the cell membrane and is a component of tight junctions.
• The protein contains transmembrane helices and a coiled coil domain, and belongs to the tight junction protein family.
• Post-translational modifications include phosphorylation and isopeptide bond formation; alternative splicing generates multiple isoforms.
• Mutations in MARVELD2 are associated with non-syndromic deafness (DFNB49).

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal region (aa 1-195); consider verifying reactivity against full-length and splice variants in relevant cell or tissue lysates.
• For WB, the predicted molecular weight is approximately 64 kDa; optimize gel percentage and transfer conditions accordingly.
• The antibody is suitable for ELISA; titration of coating antigen and antibody dilution is recommended to achieve optimal signal-to-noise ratio.
• Cross-reactivity with mouse and rat is expected; validate in the specific experimental system before large-scale studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories streamlined access to high-quality IVD raw materials, including this anti-MARVELD2 polyclonal antibody, suited for tight junction biology and hearing research. Our comprehensive portfolio features validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to support your assay development. We also specialize in sourcing rare-target reagents, providing a one-stop solution from concept to clinic.