Anti-MAGOHB Polyclonal Antibody for WB, ELISA - Q96A72

Core Product Specifications and Parameters

Biological Background: MAGOHB Function and Localization

• Encoded by the MAGOHB gene (also known as MAGOH2), protein mago nashi homolog 2 is an evolutionarily conserved core component of the exon junction complex (EJC) and the spliceosome.
  Related references:
  PMID:28502770 PMID:29301961 PMID:30705154
• Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway, contributing to mRNA surveillance and quality control.
  Related references:
  PMID:23917022
• Localizes predominantly to the nucleus, consistent with its function in pre-mRNA splicing and ribonucleoprotein particle assembly.
• Exhibits ubiquitous tissue expression, reflecting its fundamental role in constitutive RNA metabolism.
• Post-translationally modified by acetylation, and characterized as an RNA-binding protein involved in mRNA processing, splicing, and transport.

Experimental Guidance and Technical Tips

• The immunogen spans the full-length human MAGOHB protein (residues 1–148), enabling recognition of endogenous MAGOHB in Western blotting; the predicted molecular weight is ~17 kDa.
• Due to its polyclonal nature, this antibody can be used for indirect ELISA; consider optimizing coating antigen and antibody dilution for best signal-to-noise ratio.
• Cross-reactivity with rat is reported; validate detection in rat lysates or recombinant protein when using this antibody in rodent model studies.
• For Western blot, use standard denaturing and reducing conditions, and include appropriate positive and negative controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with reliable access to IVD raw materials including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This anti-MAGOHB antibody supports studies in RNA splicing, mRNA quality control, and gene expression regulation. Through our integrated supply network, we also assist with sourcing rare-target raw materials and technical consulting to streamline your assay development pipeline.