Anti-MAGEA11 Rabbit Polyclonal Antibody for WB, ELISA - P43364

Core Product Specifications and Parameters

Biological Background: MAGEA11 Function and Localization

• MAGEA11 (Melanoma-associated antigen 11), also known as cancer/testis antigen 1.11 (CT1.11) or MAGE-11, is a member of the MAGE family of tumor antigens.
• It functions as an androgen receptor coregulator, enhancing androgen receptor activity by modulating interdomain interactions within the receptor.
• MAGEA11 is implicated in embryonal development and may contribute to tumor transformation or aspects of tumor progression.
• The protein localizes to both the nucleus and cytoplasm.
• Expression is detected in a variety of tumors, including melanoma, head and neck squamous cell carcinoma, lung carcinoma, and breast carcinoma, as well as in normal tissues such as testis, ovary, prostate, breast, and adrenal gland.
• Alternative splicing of the gene has been reported, and the protein is identified as a tumor antigen with relevance in cancer immunotherapy research.

Experimental Guidance and Technical Tips

• The immunogen used to generate this antibody corresponds to the N-terminal region (amino acids 1-110) of human MAGEA11. This region may be conserved among isoforms; verify specificity in your sample system.
• For Western blotting, expect a band around 48 kDa. Optimize antibody concentration based on your sample and experimental conditions; the antibody may also be suitable for ELISA.
• Since MAGEA11 is expressed in tumor tissues and some normal tissues, appropriate tissue controls should be included when assessing expression in cancer samples.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research teams by providing a comprehensive range of IVD raw materials and sourcing services—from validated antibody pairs and optimized polyclonal antibodies to bulk ancillary reagents and rare-target procurement. With expertise in tumor antigens like MAGEA11, we help streamline your assay development by consolidating your raw material supply chain.