Anti-LZTS2 Rabbit Polyclonal Antibody for WB and ELISA - Q9BRK4

Core Product Specifications and Parameters

Biological Background: LZTS2 Function and Localization

• Leucine zipper putative tumor suppressor 2 (LZTS2), also known as LAPSER1, is a coiled-coil protein with a molecular weight of approximately 73 kDa.
• Functions as a negative regulator of katanin-mediated microtubule severing and release from the centrosome, and is required for central spindle formation and completion of cytokinesis.
• May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles necessary for transport within the elongating axon.
• Acts as a negative regulator of the Wnt signaling pathway; represses beta-catenin-mediated transcriptional activation by promoting nuclear exclusion of beta-catenin.
• Predominantly localizes to the cytoplasm, cytoskeleton, and microtubule organizing center (centrosome).
• Highly expressed in prostate and testis, with slightly lower levels in spleen, thymus, uterus, small intestine, and colon.
• Associated with key cellular processes including cell cycle, cell division, and mitosis, and is characterized as a phosphoprotein.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a C-terminal region (amino acids 470–669) of human LZTS2, which may allow detection of full-length and relevant isoforms; consider sequence alignment to verify isoform coverage.
• For western blotting, standard protocols can be employed; a band near 73 kDa is expected. Validate in cell lines or tissues with confirmed LZTS2 expression (e.g., prostate, testis, or relevant cancer cell models).
• ELISA applications are suitable; ensure the recombinant protein or peptide coating buffers and assay conditions are optimized for this antibody.
• As the antibody cross-reacts with mouse and rat, it may be useful in comparative studies; however, confirm specificity in the respective species using positive and negative controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and researchers with a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For studies on cell cycle, Wnt signaling, or cancer biology, we offer integrated sourcing of antibodies targeting LZTS2 and related pathways, along with technical support to streamline your development pipeline.