Anti-Lyve1 Rabbit Polyclonal Antibody for WB and ELISA - Q8BHC0

Core Product Specifications and Parameters

Biological Background: Lyve1 Function and Localization

• Lyve1, also known as lymphatic vessel endothelial hyaluronic acid receptor 1, CRSBP-1, or XLKD1, is a transmembrane receptor encoded by the Lyve1 gene in mouse.
• It acts as a ligand-specific transporter between the TGN and plasma membrane, involved in autocrine growth regulation, and may function as a hyaluronan transporter for catabolism within lymphatic endothelial cells or transport into lymph nodes (PubMed:10187853). Related references: PMID:10187853
• Through binding to hyaluronan matrices on leukocytes, Lyve1 promotes cell adhesion and migration across lymphatic endothelium (By similarity).
• Subcellularly, Lyve1 is a membrane protein, consistent with its transport and adhesion functions.
• The protein is characterized as a glycoprotein with a signal peptide, a transmembrane helix, and disulfide bonds, reflecting its structure as a cell surface receptor.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 30–228) corresponds to the extracellular domain, likely enhancing recognition of the native membrane-bound Lyve1; consider validating specificity in target tissue lysates.
• For Western blot, a band around 34 kDa is expected, but glycosylation may increase the apparent molecular weight; we recommend titrating the antibody and including appropriate controls.
• In ELISA applications, this antibody can be used as a capture or detection reagent; validate with recombinant protein or cell lysates.
• Given cross-reactivity with rat, the antibody may be employed in rat models; however, we advise verifying reactivity in the specific experimental system.

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