Anti-LYRM1 Rabbit Polyclonal Antibody for WB and ELISA - O43325

Core Product Specifications and Parameters

Biological Background: LYRM1 Function and Localization

• LYRM1 (LYR motif-containing protein 1) is a ~14 kDa nuclear protein encoded by the LYRM1 gene (Gene ID: 57149) in humans.
• It features a LYR motif, a domain commonly associated with proteins involved in mitochondrial respiratory chain complex assembly, though its exact role remains under study.
• The protein is localized to the nucleus, as indicated by its subcellular annotation.
• Expression is predominantly high in adipose tissue, pointing to a specialized function in fat cells.
• Functional studies suggest that LYRM1 may promote cell proliferation and inhibit apoptosis of preadipocytes, implicating it in adipogenesis and metabolic regulation.
• It is included in the human reference proteome, underscoring its fundamental biological relevance.

Experimental Guidance and Technical Tips

• The antibody was raised against a recombinant fusion protein spanning the full-length human LYRM1 (aa 1-122, NP_065157.1). Consider using this antigen for validation or competition assays.
• For Western blotting, a band at approximately 14 kDa is anticipated. Optimize loading controls and verify detection in your specific lysates, particularly from adipose tissue or preadipocyte lines.
• This polyclonal antibody cross-reacts with mouse LYRM1, enabling translational studies in rodent models. Validate cross-reactivity if applying to other species.
• Suitable for ELISA; consider pairing with a monoclonal antibody for sandwich ELISA development in IVD applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive IVD raw-material sourcing partner, supplying validated antibodies, bulk reagents, and technical support from concept to clinic. Our portfolio includes polyclonal and monoclonal antibodies against metabolism-related targets like LYRM1, ideal for developing assays in obesity and diabetes research. For specialized needs, we offer sourcing services for rare targets and tailor-made antibody pairs to accelerate your diagnostic development.