Anti-LRRFIP2 Polyclonal Antibody for WB, IF/ICC, ELISA - Q9Y608

Core Product Specifications and Parameters

Biological Background: LRRFIP2 Function and Localization

• Also known as HUFI-2, LRRFIP2 is a leucine-rich repeat flightless-interacting protein 2.
• Acts as an activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.
• Positively regulates Toll-like receptor (TLR) signaling by competing with the negative regulator FLII for MYD88 binding.
• Widely expressed, with highest levels in heart and skeletal muscle.
• Contains a coiled coil domain and undergoes alternative splicing.
• Identified as a phosphoprotein; post-translational modifications may regulate its function.

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fusion protein covering amino acids 150-340 of human LRRFIP2 (NP_060194.1). This region may contain functional domains relevant to Wnt and TLR signaling. Consider epitope accessibility when designing experiments.
• Recommended applications include Western blot (WB), immunofluorescence/immunocytochemistry (IF/ICC), and ELISA. For optimal results, validate the antibody in your specific sample system and use appropriate controls.
• Expected band size for WB is approximately 82 kDa. Note that post-translational modifications or isoforms could cause slight shifts.
• Cross-reactivity is reported for human, mouse, and rat. For other species, sequence homology should be checked before use.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting. For Wnt signaling and TLR pathway research, we offer validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents. Contact CamelBio to explore custom sourcing for rare targets and accelerate your assay development from concept to clinic.