Anti-LRP1 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q07954

Core Product Specifications and Parameters

Biological Background: LRP1 Function and Localization

• Also known as Prolow-density lipoprotein receptor-related protein 1 (LRP1), alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER), and CD91.
• Functions as an endocytic receptor mediating endocytosis and phagocytosis of apoptotic cells, and acts as a receptor for alpha-2-macroglobulin, facilitating clearance of chylomicron remnants and protease complexes.
  Related references: PMID:11907044, PMID:12713657, PMID:1702392, PMID:26142438
• Acts as a receptor for TAU/MAPT, controlling its endocytosis and intercellular spread, with implications for neurodegenerative tauopathies.
  Related references: PMID:32296178
• Modulates APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling, and neurotransmission.
  Related references: PMID:12888553
• Serves as a receptor for IGFBP3 to mediate cell growth inhibition.
  Related references: PMID:9252371
• Functions as a receptor for Pseudomonas aeruginosa exotoxin A and yellow fever virus during microbial infection.
• Predominantly expressed in liver, brain, and lung.
• Localizes to the cell membrane, coated pits, cytoplasm, nucleus, Golgi outposts, and microtubule organizing centers; subject to post-translational modifications including acetylation, glycosylation, and phosphorylation, and contains EGF-like and LDL-receptor class A domains.

Experimental Guidance and Technical Tips

• For Western blotting, consider using a low-percentage (e.g., 3–8%) SDS-PAGE gel and extended transfer times to accommodate the high molecular weight (~505 kDa) of full-length LRP1. Validate detection in relevant human, mouse, or rat samples.
• In IHC-P, antigen retrieval may be necessary for optimal staining; test appropriate retrieval buffers and conditions.
• For ELISA, the immunogen sequence (C-terminal residues 4401–4500) can serve as a coating antigen, or validate against natural LRP1 ligands in the relevant sample system.
• As a polyclonal antibody, it recognizes multiple epitopes, which may enhance sensitivity but also increase the risk of non-specific binding; include appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers one-stop access to IVD raw materials and technical support, reliably supplying validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents for diagnostic development. This LRP1 antibody supports research in lipid metabolism, signal transduction, and neurodegeneration, and we also assist with rare target raw-material sourcing to streamline your workflow from concept to clinic.