Anti-LRP1 Rabbit Monoclonal Antibody for WB, ELISA - Q07954

Core Product Specifications and Parameters

Biological Background: LRP1 Function and Localization

• Endocytic receptor involved in endocytosis and phagocytosis of apoptotic cells; required for early embryonic development. Related references: PMID:11907044, PMID:12713657
• Participates in cellular lipid homeostasis and the plasma clearance of chylomicron remnants and alpha-2-macroglobulin complexes. Related references: PMID:1702392, PMID:26142438
• Functions as a receptor for TAU/MAPT, controlling its endocytosis and spread, and modulates APP metabolism, kinase signaling, and neuronal calcium signaling. Related references: PMID:32296178, PMID:12888553
• Acts as a receptor for IGFBP3 to mediate cell growth inhibition. Related references: PMID:9252371
• (Microbial infection) Serves as a receptor for Pseudomonas aeruginosa exotoxin A and yellow fever virus.
• Subcellular localization includes cell membrane, coated pits, cytoplasm, nucleus, Golgi outpost, and microtubule organizing center.
• Most abundant in liver, brain, and lung.
• Large glycoprotein with EGF-like repeats, calcium-binding sites, and disulfide bonds; post-translational modifications include acetylation and phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen targets a C-terminal peptide (aa 4400-4500). Verify that the antibody recognizes the full-length 505 kDa protein by WB in relevant lysates.
• High endogenous expression in liver, brain, and lung makes these tissues suitable as positive controls.
• For cross-reactivity, validate performance in mouse and rat samples; consider sequence alignment of the immunogen region.
• Due to the large molecular weight, use an appropriate gel percentage (e.g., 6% SDS-PAGE) and extended transfer times; include a high-molecular-weight marker.
• In ELISA applications, pairing with a detection antibody against a distinct epitope may improve sensitivity and specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your comprehensive partner for IVD raw-material sourcing, connecting diagnostic manufacturers and research laboratories with high-quality reagents and technical support from concept to clinic. The LRP1 monoclonal antibody exemplifies our capability to supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents for lipid metabolism, endocytosis, and neurodegeneration research. Beyond this product, we excel in sourcing rare target raw materials and delivering customized solutions to accelerate your assay development and production needs.