Anti-LHX6 Polyclonal Antibody for WB, ELISA - Q9UPM6

Core Product Specifications and Parameters

Biological Background: LHX6 Function and Localization

• LHX6 is a LIM/homeobox transcription factor also known as LHX6.1, encoded by the LHX6 gene.
• It functions as a transcription factor required for the migration and development of GABAergic interneurons, particularly in the specification of cortical subtypes.
• LHX6 is involved in the migration of interneuron precursors from the subpallium to the cerebral cortex (By similarity).
• The protein localizes to the nucleus, consistent with its role in transcriptional regulation.
• It contains LIM domains and a homeobox DNA-binding domain, classifying it as a zinc-dependent, DNA-binding developmental regulator.
• Alternative splicing of LHX6 produces multiple isoforms, potentially modulating its function.
• Key biological processes annotated for LHX6 include neurogenesis, differentiation, and developmental regulation.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 143-392) spans the homeobox domain and flanking regions; consider using recombinant LHX6 protein or nuclear extracts from neuronal cells as positive controls.
• For Western blotting, the predicted molecular weight of LHX6 is ~40 kDa; ensure membrane blocking and antibody incubation are optimized to minimize non-specific binding inherent to polyclonal preparations.
• The antibody's reported cross-reactivity with mouse and rat allows for validation in rodent models of interneuron development; confirm reactivity in your specific strain or tissue.
• In ELISA applications, the recombinant immunogen may serve as a coating antigen; titrate the antibody to determine optimal working concentration for your assay format.
• As a polyclonal antibody, it may recognize multiple isoforms or post-translationally modified forms; validate band patterns in the relevant sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This LHX6 antibody exemplifies our commitment to sourcing rare-target reagents for neuroscience research, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. Whether you need further characterization or additional neurodevelopmental biomarkers, CamelBio bridges your procurement gap with reliable supply solutions.