Anti-LHX4 Polyclonal Antibody for WB, IHC-P, ELISA - Q969G2

Core Product Specifications and Parameters

Biological Background: LHX4 Function and Localization

• LHX4 encodes a LIM/homeobox transcription factor implicated in the development of respiratory control mechanisms and normal lung growth and maturation.
• The protein preferentially binds to methylated DNA, a property demonstrated in biochemical assays. Related references: PMID:28473536
• LHX4 contains LIM domains, which are zinc-binding protein interaction modules, and a homeobox domain for DNA binding, classifying it as a transcription regulator.
• Subcellular localization is confined to the nucleus, where it likely influences gene expression patterns.
• UniProt associates LHX4 with keywords including chromosomal rearrangement, disease variant (linked to dwarfism), proto-oncogene, and metal-binding, indicating roles in development and disease.
• Structural studies (3D-structure keyword) have been reported, though details are not specified here.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 121–390, covering most of the protein, and is expected to recognize both full-length LHX4 and potential isoforms. Confirm reactivity in your sample system.
• For western blotting, the predicted molecular weight is 43 kDa. Use appropriate denaturing conditions to resolve the band.
• In immunohistochemistry (paraffin), validate the antibody in human, mouse, or rat lung tissues where LHX4 is functionally relevant.
• For ELISA, the polyclonal nature may provide higher sensitivity, but background should be assessed with appropriate controls.
• Consider testing cross-reactivity with relevant model organisms (human, mouse, rat) as indicated.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers IVD manufacturers, diagnostic labs, and research institutes seamless access to validated raw materials like this LHX4 rabbit polyclonal antibody, targeting transcription factors involved in respiratory and developmental biology. Our supply portfolio includes optimized antibody pairs, bulk ancillary reagents, and rare target sourcing, bridging your workflow from discovery to clinical application. Contact us to explore tailored procurement solutions for your next diagnostic project.