Anti-LGR6 Rabbit Monoclonal Antibody for WB, IF/ICC, ELISA - Q9HBX8

Core Product Specifications and Parameters

Biological Background: LGR6 Function and Localization

• LGR6 (Leucine-rich repeat-containing G protein-coupled receptor 6) serves as a receptor for R-spondins (RSPO1–RSPO4), potentiating canonical Wnt signaling by interacting with phosphorylated LRP6 and frizzled receptors.

• In contrast to typical GPCRs, LGR6 does not signal through heterotrimeric G proteins.

• The protein marks multipotent stem cells in the epidermis and exhibits tumor suppressor activity.

• LGR6 localizes to the cell membrane.

• Post‑translational modifications include disulfide bond formation and glycosylation, consistent with its GPCR nature.

• Alternative splicing generates multiple LGR6 isoforms.

• LGR6 belongs to the leucine‑rich repeat (LRR)‑containing GPCR family, with an extensive extracellular domain composed of these repeats.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 801–900 of human LGR6; consider verifying reactivity in your target species.

• The antibody is qualified for Western blot, IF/ICC, and ELISA applications; optimal working dilutions should be determined empirically.

• As cross‑reactivity is reported for human and rat, validate performance in rat samples if used beyond human.

• Include appropriate positive (tissue or cell line known to express LGR6, such as skin or stem cells) and negative controls.

CamelBio: Your One‑Stop Sourcing Bridge

CamelBio streamlines IVD raw‑material procurement by offering validated monoclonal antibodies, like this anti‑LGR6 rabbit mAb, for stem cell and Wnt signaling research. Our portfolio includes optimized antibody pairs, bulk ancillary reagents, and sourcing for rare‑target raw materials. Partner with CamelBio to accelerate your diagnostic development from concept to clinic.