Anti-LARP6 Polyclonal Antibody for WB, ELISA - Q9BRS8

Core Product Specifications and Parameters

Biological Background: LARP6 Function and Localization

• LARP6 (La-related protein 6), also known as Acheron (Achn), is a member of the La ribonucleoprotein domain family.
• It regulates coordinated translation of type I collagen alpha-1 (COL1A1) and alpha-2 (COL1A2) mRNAs by binding a stem-loop structure in their 5' UTR, stabilizing the mRNAs.
• This translational regulation requires vimentin (VIM) and myosin-10 (MYH10) filaments, as well as the helicase DHX9.
• LARP6 localizes to both the cytoplasm and nucleus.
• The protein is expressed in numerous tissues and undergoes post-translational modifications including acetylation, phosphorylation, and alternative splicing.
• Keywords associated with LARP6 include RNA-binding and translation regulation, highlighting its role in post-transcriptional control.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–320) of human LARP6, which is expected to be conserved across species (human, mouse, rat).
• For Western blot, a band around 55 kDa is anticipated; include appropriate molecular weight markers and validate in a relevant cell line or tissue expressing LARP6.
• In ELISA, the polyclonal nature may allow flexible assay design (e.g., capture or detection); proper pairing and optimization are recommended.
• Considering the polyclonal source, lot-to-lot consistency should be monitored for critical quantitative applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting, covering every stage from concept to clinic. This anti-LARP6 polyclonal antibody supports research into collagen biology, fibrosis, and translational regulation. Our supply portfolio includes validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to accelerate your assay development.