Anti-Langerin/CD207 Rabbit Polyclonal Antibody for WB, ELISA - Q9UJ71

Core Product Specifications and Parameters

Biological Background: Langerin/CD207 Function and Localization

• Langerin, encoded by CD207, is a type II transmembrane C-type lectin receptor primarily expressed on Langerhans cells.
• Functions as a calcium-dependent lectin with mannose-binding specificity; induces Birbeck granule formation and regulates membrane superimposition and zippering.
• Recognizes a variety of glycans including sulfated structures, keratan sulfate, and β-glucans; facilitates antigen uptake and processing for presentation to T cells.
• Acts as a major receptor for fungal pathogens such as Candida, Saccharomyces, and Malassezia furfur on primary Langerhans cells.
• Plays a protective role against HIV-1 infection by binding high-mannose structures on viral envelope glycoproteins, directing the virus to Birbeck granules for degradation.
• Localizes to the plasma membrane and intracellular Birbeck granules; tissue expression is restricted to Langerhans cells and certain brain tumors (astrocytoma, malignant ependymoma).
• Post-translational modifications include glycosylation and disulfide bond formation; structural features include a coiled-coil region and a single transmembrane helix.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 70–200), which contains the carbohydrate recognition domain; consider optimizing sample preparation to preserve native conformation for WB.
• Predicted molecular weight is approximately 37 kDa; validate migration under reducing and non‑reducing conditions, as disulfide bonds may influence electrophoretic mobility.
• For ELISA, the antibody can be tested as a capture or detection reagent; verify performance with recombinant protein or cell lysates to establish working concentrations.
• Cross‑reactivity with mouse and rat suggests a conserved epitope; confirm specificity in the relevant tissue or cell line before quantitative assays.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio specializes in providing integrated IVD raw material solutions for diagnostic manufacturers and research laboratories. With this anti‑Langerin/CD207 polyclonal antibody, we support your research into Langerin‑mediated immune functions and antigen presentation. Beyond individual antibodies, we offer validated antibody pairs, optimized monoclonal/polyclonal reagents, bulk ancillary materials, and rare‑target sourcing to accelerate your assay development from concept to clinic.