Anti-LACTB Polyclonal Antibody for WB and ELISA - P83111

Core Product Specifications and Parameters

Biological Background: LACTB Function and Localization

• LACTB (Serine beta-lactamase-like protein LACTB, mitochondrial), also designated MRPL56 and G24, is a member of the serine protease family.
• Functions as a mitochondrial serine protease that regulates mitochondrial lipid metabolism by decreasing protein levels of PISD, a key enzyme in phosphatidylethanolamine synthesis. Related references: PMID:28329758
• Acts as a tumor suppressor, inhibiting proliferation of multiple breast cancer cell types; likely linked to its role in mitochondrial lipid metabolism. Related references: PMID:28329758
• Localizes exclusively to mitochondria.
• Expressed predominantly in skeletal muscle, with potential roles in muscle metabolism.
• Undergoes alternative splicing and acetylation; classified as a hydrolase and a reference proteome member.
• Additional keywords: lipid metabolism, protease, tumor suppressor, transit peptide.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 120–290 of human LACTB (NP_116246.2), which may contribute to specific recognition of endogenous LACTB by this polyclonal antibody.
• For WB, the predicted molecular weight is ~61 kDa; consider using whole‑cell or mitochondrial‑enriched lysates from skeletal muscle or breast cancer lines. Include appropriate loading controls and validate detection in your sample system.
• In ELISA applications, the recombinant immunogen or purified native protein can serve as the coating antigen; optimize coating concentration and buffer conditions for your assay format.
• Cross‑reactivity with human and mouse LACTB suggests that this antibody can be used for both human and rodent studies, but confirm species‑specific reactivity if quantitative data are required.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your trusted partner for IVD raw‑material sourcing, providing diagnostic manufacturers and research labs with a seamless supply chain from discovery to clinical application. This LACTB polyclonal antibody supports research in mitochondrial biology and oncology; CamelBio further offers validated antibody pairs, optimized bulk reagents, and tailored sourcing solutions for rare targets—empowering your assay development pipeline with efficiency and reliability.