Anti-KTN1 Polyclonal Antibody for WB, IHC-P, ELISA - Q86UP2

Core Product Specifications and Parameters

Biological Background: Kinectin Function and Localization

• Kinectin, also known as CG-1 antigen or kinesin receptor, is a large integral membrane protein primarily localized to the endoplasmic reticulum (ER) membrane.
• Functions as a receptor for kinesin, mediating kinesin-driven vesicle motility along microtubules, which is essential for intracellular transport.
• Upon integrin aggregation by fibronectin, kinectin accumulates in integrin-based adhesion complexes (IAC), suggesting a role in cell adhesion and signaling.
• Exhibits tissue-specific expression, with high levels in peripheral blood lymphocytes, testis, and ovary, and lower levels in spleen, thymus, prostate, small intestine, and colon.
• Undergoes alternative splicing, producing multiple isoforms, and contains coiled-coil domains likely important for protein-protein interactions.
• Post-translational modifications include phosphorylation and glycosylation, which may regulate its localization and function; direct protein sequencing evidence supports its primary structure.

Experimental Guidance and Technical Tips

• The immunogen was designed against the N-terminal region (aa 1-100) of human KTN1; consider using this antibody for detection of full-length kinectin in human samples.
• For Western blotting, note the predicted molecular weight of approximately 156 kDa; optimize transfer conditions for high-molecular-weight proteins.
• Validate antibody specificity in relevant biological systems, such as human cell lines expressing kinectin, before use in IHC-P or ELISA.
• Cross-reactivity is reported for human; for other species, sequence homology should be checked as the antibody may not recognize orthologs.

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