Anti-KLHL42 Rabbit Polyclonal Antibody for IHC-P, ELISA - Q9P2K6

Core Product Specifications and Parameters

Biological Background: KLHL42 Function and Localization

• KLHL42 (Kelch-like protein 42), also known as Ctb9 or KLHDC5, is a substrate-specific adapter of the BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.
• It plays a critical role in mitotic progression and cytokinesis by mediating the ubiquitination and subsequent degradation of KATNA1.
• Involved in microtubule dynamics throughout mitosis, localizing to the cytoplasm and mitotic spindle.
• Belongs to the kelch repeat family, containing BTB and kelch domains that facilitate substrate recognition and complex assembly.
• Keywords indicate involvement in cell cycle, cell division, and ubiquitin conjugation pathway.

Experimental Guidance and Technical Tips

• For IHC-P, perform antigen retrieval and validate with positive and negative control tissues.
• For ELISA, test the antibody in direct or indirect format, optimizing coating and detection conditions per standard protocols.
• Since this is a polyclonal antibody, lot-to-lot consistency may vary; we recommend validating each new lot in your specific assay.
• The antibody cross-reacts with mouse, enabling studies in mouse models.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with reliable access to IVD raw materials, including validated antibodies like this anti-KLHL42 polyclonal antibody, supporting studies on ubiquitin-proteasome system and cell division. As a one-stop sourcing partner, we connect you with high-quality raw materials, technical services, and consulting from concept to clinic, including bulk ancillary reagents and rare target sourcing.