Anti-KIR3DL3 Polyclonal Antibody for WB, IHC-P, ELISA - Q8N743

Core Product Specifications and Parameters

Biological Background: KIR3DL3 Function and Localization

• KIR3DL3, also known as CD158Z or KIRC1, is a member of the killer cell immunoglobulin-like receptor (KIR) family.
• It is expressed on the surface of natural killer (NK) cells and likely functions as an inhibitory receptor, contributing to the regulation of NK cell cytotoxicity.
• The protein is a type I transmembrane glycoprotein with extracellular immunoglobulin domains and a cytoplasmic tail that may mediate inhibitory signaling.
• Subcellularly, KIR3DL3 localizes to the cell membrane.
• According to UniProt keywords, it features a signal peptide, multiple immunoglobulin domains, disulfide bonds, and a transmembrane helix, consistent with its role as a cell surface receptor.

Experimental Guidance and Technical Tips

• For western blotting (WB), start with a standard dilution range and optimize based on the target expression level in your sample system.
• In immunohistochemistry on paraffin-embedded sections (IHC-P), antigen retrieval steps may be necessary; validate the staining pattern in relevant tissue controls.
• The antibody’s cross-reactivity with mouse and rat KIR3DL3 supports comparative studies across species, but confirm reactivity in your specific experimental context.
• Polyclonal antibodies may exhibit lot-to-lot variation; consider re-validating critical experiments when switching to a new production batch.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for in-vitro diagnostic raw materials, providing validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target sourcing. For projects targeting KIR3DL3 and other NK cell inhibitory receptors, we offer tailored raw-material solutions to support your immuno-oncology and immune monitoring research from concept to clinic.