Anti-Kinesin light chain 1 (KLC1) Rabbit Monoclonal Antibody for WB, ELISA - Q07866

Core Product Specifications and Parameters

Biological Background: Kinesin light chain 1 Function and Localization

• Kinesin light chain 1 (KLC1) is a component of the kinesin motor complex, associating with kinesin heavy chains to facilitate microtubule-based transport.
• It plays a role in organelle transport along microtubules, acting as a force-producing protein (PubMed:21385839). Related references: PMID:21385839
• The light chain likely functions in coupling cargo to the heavy chain or modulating the ATPase activity of the motor complex.
• KLC1 localizes to the cytoplasm, cytoskeleton, cell projections such as growth cones, and cytoplasmic vesicles, consistent with its transport functions.
• It is widely expressed in tissues, with highest abundance in brain and spine, reflecting its importance in neuronal transport.
• The protein contains TPR repeats and coiled-coil domains, and is subject to phosphorylation and calcium regulation, influencing motor activity and cargo binding.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a sequence within the central region of human KLC1 (amino acids 450–550), which may confer specificity for detecting the protein.
• For Western blot, consider using whole-cell or tissue lysates from human or rat brain or spinal cord, where KLC1 is most abundant. Validate antibody specificity in your sample system.
• For ELISA, pairing with a matched detection antibody or recombinant protein control can enhance assay reliability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive suite of IVD raw materials, from validated antibody pairs and optimized monoclonal/polyclonal antibodies to bulk ancillary reagents and rare target sourcing. This KLC1 antibody supports research into intracellular transport and motor protein biology. As a one-stop partner, we bridge the gap from concept to clinic with reliable supply and expert technical support.