Anti-KIF1C Polyclonal Antibody for WB, ELISA - O43896

Core Product Specifications and Parameters

Biological Background: KIF1C Function and Localization

• Kinesin-like protein KIF1C is a member of the kinesin superfamily of microtubule-dependent motor proteins, also known by aliases SAX2, LTXS1, SATX2, SPAX2, and SPG58.
• Its primary function is as a motor for the retrograde transport of Golgi vesicles to the endoplasmic reticulum, exhibiting microtubule plus end-directed motility.
• KIF1C contains characteristic structural features including an ATP-binding domain and coiled-coil regions, essential for its motor activity and cargo interaction.
• Subcellularly, KIF1C localizes to the cytoplasm and associates with the cytoskeleton, consistent with its role in intracellular trafficking.
• It is expressed in all human tissues examined, with the highest abundance observed in heart and skeletal muscle, suggesting important roles in these highly active tissues.
• Post-translational modifications, such as phosphorylation and methylation, regulate KIF1C function, and mutations in the gene are associated with neurodegenerative disorders, as highlighted by disease variant keywords.
• Proteomic identification and a reference proteome entry underscore its widespread study in cellular transport and pathology.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a specific fragment (aa 810-960) of human KIF1C, which may enhance detection specificity in relevant sample systems.
• For Western blot (WB) applications, consider using whole cell lysates from human, mouse, or rat tissues, with an expected band around 123 kDa.
• In ELISA assays, validate coating antigens and detection conditions with control samples to ensure optimal signal-to-noise ratios.
• Due to the conserved nature of KIF1C, cross-reactivity with other species may occur; verify in your experimental system if using species beyond those listed.
• Optimize blocking and antibody dilution conditions empirically, as performance can vary with sample type and preparation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with streamlined access to IVD raw materials, including validated antibody pairs and optimized polyclonal antibodies like this anti-KIF1C reagent. Our comprehensive portfolio supports intracellular transport and neurodegenerative disease research, offering bulk ancillary reagents and rare target sourcing to accelerate your assay development. Partner with us to bridge the gap from concept to clinic with reliable, high-quality raw materials.