Anti-KCNS3 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q9BQ31

Core Product Specifications and Parameters

Biological Background: KCNS3 Function and Localization

• KCNS3, also known as Kv9.3, is a member of the potassium voltage-gated channel subfamily S, encoded by the KCNS3 gene. It functions as a regulatory subunit that does not form functional channels on its own.
  Related references: PMID:10484328
• The protein modulates the activity of KCNB1 delayed-rectifier potassium channels by slowing deactivation and inactivation kinetics, forming heterotetrameric channels.
  Related references: PMID:10484328
• KCNS3 is localized to the cell membrane, consistent with its role as an ion channel regulatory subunit.
• It is highly expressed in lung tissue, with detection also in placental arteries, veins, syncytiotrophoblast, and blood vessel endothelium.
  Related references: PMID:22943705; PMID:10484328
• The protein is classified under voltage-gated ion channels and contains transmembrane helices, contributing to potassium transport and membrane potential regulation.
• KCNS3 has been identified in proteomic analyses and is part of the reference proteome.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1–180 of human KCNS3. This N-terminal region may share homology with other Kv channel subunits; consider verifying specificity in target tissue.
• For Western blot, the predicted molecular weight of KCNS3 is 56 kDa; validate detection by observing a band at this size in lysates from tissues with high KCNS3 expression (e.g., lung).
• In IHC-P, optimize antigen retrieval and antibody dilution using positive control tissues such as lung or placenta.
• For ELISA, consider using recombinant KCNS3 protein fragments to assess binding affinity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting for ion channel research. This KCNS3 rabbit polyclonal antibody exemplifies our commitment to supplying high-quality reagents for potassium channel studies. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents, ensuring seamless support from target selection to assay validation.