Anti-KCNS2 (KV9.2) Rabbit Polyclonal Antibody for WB, IF-P, ELISA - Q9ULS6

Core Product Specifications and Parameters

Biological Background: KCNS2 Function and Localization

• KCNS2 (Potassium Voltage-Gated Channel Modifier Subfamily S Member 2) encodes a delayed-rectifier potassium channel regulatory subunit, also known as Kv9.2, that modulates voltage-gated potassium channel activity.
• It functions as an auxiliary subunit that does not form functional homomeric channels but assembles with KCNB1 and KCNB2 to form heterotetrameric channels, altering their kinetics, expression levels, and voltage dependence of inactivation.
• The subunit induces significant shifts in the half-inactivation potential toward more polarized values, thereby regulating neuronal excitability and action potential repolarization.
• KCNS2 is primarily localized to the plasma membrane (cell membrane), consistent with its role in modulating ion flux.
• Post-translational modifications and interactions of KCNS2 are not fully characterized, but its integration into heteromeric complexes is essential for proper channel gating.
• Belongs to the voltage-gated potassium channel family, specifically the regulatory subunits that include KCNS1, KCNS2, and KCNS3, each with distinct modulatory properties.
• While no tissue-specific expression data is provided, Kv9.2-containing channels are broadly implicated in excitable tissues, particularly in the nervous system.
• Keywords associated with KCNS2 include: Ion channel, Potassium channel, Voltage-gated channel, Transmembrane helix, Membrane, and Transport, reflecting its fundamental role in electrochemical signaling.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal region (amino acids 1–187) of human KCNS2, which is expected to generate antibodies recognizing both native and denatured forms; consider this when selecting applications.
• For Western blotting (WB), the predicted molecular weight of KCNS2 is approximately 54 kDa; validate the band size in your specific cell or tissue lysate, and account for possible post-translational modifications.
• In immunofluorescence on paraffin-embedded sections (IF-P), anticipate membrane staining; include appropriate controls to confirm specificity, as endogenous expression levels may vary.
• This polyclonal antibody has been shown to react with human, mouse, and rat orthologs, but cross-reactivity with other species should be verified.
• For ELISA applications, the recombinant immunogen may serve as a positive control; consider optimizing coating conditions and antibody dilution for your assay system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD manufacturers and research laboratories, providing one-stop access to high-quality raw materials including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This KCNS2 antibody supports research into potassium channel regulation and neurological disorders, and CamelBio can assist with sourcing antibodies against other ion channel subunits or related targets. For specialized requirements such as rare target raw materials or customized immunoreagents, our team offers tailored sourcing solutions to accelerate your diagnostic development.