Anti-KCNJ6 Rabbit Polyclonal Antibody for WB and ELISA - P48051

Core Product Specifications and Parameters

Biological Background: KCNJ6 / GIRK2 Function and Localization

• Encodes the G protein-activated inward rectifier potassium channel 2 (GIRK2), a member of the inwardly rectifying potassium channel family (subfamily J, member 6).
• Mediates inward rectification, allowing potassium influx more readily than efflux; voltage dependence is modulated by extracellular potassium levels.
• Inward rectification results primarily from blockage of outward current by intracellular magnesium.
• Plays a role in the regulation of insulin secretion by glucose and neurotransmitters via G protein-coupled receptor signaling.
• Localizes to the cell membrane as a multi-pass transmembrane protein.
• Most abundant in cerebellum, with lower expression in pancreatic islets and exocrine pancreas.
• Associated with disease variants including congenital generalized lipodystrophy and intellectual disability.
• Subject to phosphorylation and involves potassium ion transport.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1-80); consider this when assessing isoform specificity.
• Predicted molecular weight is 48 kDa; validate with appropriate molecular weight markers in WB.
• Reactivity confirmed with human and mouse samples; test cross-reactivity in the species of interest before use.
• Suitable for WB under standard conditions; consider optimizing blocking and antibody dilution for your system.
• ELISA application may require coating with recombinant protein or cell lysates; perform titration experiments for best signal.

CamelBio: Your One-Stop Sourcing Bridge

As a dedicated IVD raw-material supplier, CamelBio facilitates your assay development with a comprehensive portfolio of validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For ion channel targets like KCNJ6/GIRK2, we offer sourcing solutions for rare targets and technical consultation to accelerate your diagnostic or research program from concept to clinic.