Anti-KCNIP2 Polyclonal Antibody for WB and ELISA - Q9NS61

Core Product Specifications and Parameters

Biological Background: KCNIP2 Function and Localization

• KCNIP2, also known as KChIP2, is a regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. It modulates channel density, inactivation kinetics, and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Related references: PMID:10676964, PMID:11287421, PMID:11684073
• It facilitates trafficking of KCND2 and KCND3 potassium channel subunits to the cell surface. Related references: PMID:12829703
• KCNIP2 may be required for the expression of transient outward potassium currents (I(To)) in the heart (By similarity).
• Tissue expression: KCNIP2 is prominently expressed in brain, colocalizing with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is additionally expressed in heart and umbilical vein endothelial cells, but not in fetal heart.
• Subcellular localization is primarily at the cell membrane, likely anchored via palmitoylation (as indicated by lipoprotein and palmitate keywords).
• The protein contains EF-hand calcium-binding motifs, classifying it as a neuronal calcium sensor subject to phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 1-90 of human KCNIP2) targets the N-terminal region—consider potential isoform specificity and verify using lysates from relevant tissues (e.g., brain or heart).
• For Western blot, expect a band around 31 kDa. Given indicated cross-reactivity with mouse and rat, the antibody may be suitable for comparative studies across species; validate in the appropriate sample system.
• For ELISA, ensure the coating antigen matches the immunogen region and optimize assay conditions empirically.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for IVD raw materials, supporting ion channel research and diagnostic development. This anti-KCNIP2 polyclonal antibody exemplifies our offering of validated polyclonal antibodies for critical targets. Beyond individual reagents, we provide validated antibody pairs, optimized recombinant proteins, and custom sourcing for rare targets—helping you streamline the journey from discovery to clinical application.