Anti-KAT8/MYST1/MOF Monoclonal Antibody for IF/ICC, IHC-P, ELISA - Q9H7Z6

Core Product Specifications and Parameters

Biological Background: KAT8/MYST1/MOF Function and Localization

• Histone acetyltransferase that catalyzes acetylation of histone H4 at specific lysines (H4K5, H4K8, H4K16) depending on the complex context, regulating chromatin structure and gene expression. Related references: PMID:12397079 PMID:16227571 PMID:16543150
• Core component of the MSL complex, mediating H4K16 acetylation to prevent chromatin compaction and ensure chromosome stability and gene dosage compensation. Related references: PMID:12397079 PMID:16227571 PMID:16543150 PMID:33837287
• Part of the NSL complex, catalyzing H4K5 and H4K8 acetylation at transcription start sites to promote transcription initiation. Related references: PMID:20018852 PMID:22547026 PMID:33657400
• Localizes to the nucleus and chromosomes, and also associates with mitochondrial DNA to regulate respiratory gene expression. Related references: PMID:27768893
• Acetylates non-histone proteins including TP53/p53, IRF3, and ALKBH5, influencing processes such as DNA damage response, antiviral immunity, and RNA demethylation. Related references: PMID:17189187 PMID:19854137 PMID:37369679
• Contains zinc-finger and chromodomain regions; classified as a transferase, acyltransferase, and chromatin regulator.
• Protein propionylation activity reported, expanding its functional repertoire in post-translational modifications. Related references: PMID:29321206
• Relevant to human disease: variants linked to intellectual disability.

Experimental Guidance and Technical Tips

• For immunofluorescence (IF/ICC, IF-P), consider permeabilization and fixation conditions appropriate for nuclear targets.
• In immunohistochemistry (IHC-P), antigen retrieval may be necessary; validate in positive control tissues with known KAT8 expression.
• For ELISA, use the recombinant protein immunogen region as a positive control if available.
• The antibody is rabbit monoclonal, ensuring batch-to-batch consistency.
• Cross-reacts with human and rat; verify reactivity in other species if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides integrated access to IVD raw materials, including validated monoclonal and polyclonal antibodies, optimized for assays in epigenetics and chromatin biology. Our KAT8/MYST1/MOF antibody supports research into histone modifications and gene regulation. We also source bulk ancillary reagents and offer technical consulting to accelerate your diagnostic development.