Anti-KAT6B Rabbit Polyclonal Antibody for WB, ELISA - Q8WYB5

Core Product Specifications and Parameters

Biological Background: KAT6B Function and Localization

• Histone acetyltransferase that may act as both a transcriptional activator and repressor; required for RUNX2-dependent transcriptional activation.
• Component of the MOZ/MORF complex which possesses histone H3 acetyltransferase activity, contributing to chromatin remodeling.
• May be involved in cerebral cortex development.
• Known by several aliases including MORF, MOZ2, and MYST4; belongs to the MYST family of acetyltransferases.
• Subcellular localization is predominantly nuclear, consistent with its role in chromatin modification.
• Ubiquitously expressed, with particularly high levels found in heart, pancreas, testis, and ovary.
• Contains zinc fingers (e.g., C2HC type) and undergoes post-translational modifications such as acetylation, phosphorylation, and ubiquitination.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a peptide within amino acids 400-500 of human KAT6B; consider peptide competition assays to verify binding specificity.
• For Western blot analysis, use a low-percentage gel (e.g., 6–8%) due to the large protein size (231 kDa); extended transfer times may be necessary for efficient membrane transfer.
• In ELISA, the synthetic peptide immunogen can serve as a positive control; validate cross-reactivity with homologous proteins from mouse and rat in the relevant sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, supporting research and diagnostic development from concept to clinic. For chromatin and transcriptional regulation studies involving KAT6B, we can supply validated antibody pairs, optimized polyclonal and monoclonal reagents, bulk ancillary materials, and customized procurement for rare-target raw materials. Our integrated supply chain enables seamless access to the critical components needed for your assay workflows.