Anti-K-Cadherin (CDH6) Rabbit Polyclonal Antibody for WB, ELISA - P55285

Core Product Specifications and Parameters

Biological Background: K-Cadherin (CDH6) Function and Localization

• Cadherin-6 (CDH6), also known as kidney cadherin (K-cadherin), is a classical cadherin calcium-dependent cell adhesion protein.
• It preferentially mediates homophilic cell-cell interactions, contributing to the sorting of heterogeneous cell types.
• CDH6 is a single-pass type I membrane protein localized at the cell membrane.
• It is highly expressed in the brain, cerebellum, and kidney, with weaker expression in lung, pancreas, and gastric mucosa; also detected in certain liver and kidney carcinomas.
• The protein contains cadherin repeats, a transmembrane domain, and is subject to proteolytic cleavage on basic residues and phosphorylation; it is also a glycoprotein.
• Structural studies indicate calcium-binding motifs essential for its adhesive function.
• It belongs to the cadherin superfamily and has a distinct tissue distribution compared to other cadherins.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal extracellular region (aa 1-250), which is likely involved in homophilic binding; this region may be suitable for detecting full-length cadherin-6.
• For Western blot, a band at approximately 88 kDa is expected; consider using reducing conditions and an appropriate gel percentage.
• Cross-reactivity with mouse and rat is indicated; validate in the relevant sample system (e.g., brain or kidney lysates) to confirm reactivity.
• For ELISA, the antibody can be used for direct or indirect detection of captured antigen; consider pairing with a matched detection antibody if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines your IVD raw material procurement with a comprehensive portfolio that includes validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For researchers and diagnostic developers focusing on cell adhesion and cadherin biology—particularly studies involving K-Cadherin (CDH6) in cancer or tissue-specific expression—we provide reliable access to high-quality antibodies like this anti-CDH6 rabbit pAb. Our team also supports rare target sourcing and technical consultation to help you move from concept to clinic efficiently.