Anti-JDP2 Polyclonal Antibody for WB and ELISA - Q8WYK2

Core Product Specifications and Parameters

Biological Background: JDP2 Function and Localization

• Encoded by the JDP2 gene, Jun dimerization protein 2 (JDP2) is a member of the AP-1 transcription factor complex and functions as a transcriptional repressor.
• Represses transactivation mediated by the Jun family of proteins, thereby modulating AP-1-dependent gene expression.
• Plays a role in multiple AP-1-associated biological processes, including UV-induced apoptosis, cell differentiation, tumorigenesis, and antitumorigenesis.
• Can recruit histone deacetylase 3 (HDAC3) to the JUN promoter, facilitating local histone deacetylation and chromatin condensation to silence transcription.
• May directly regulate histone modifications and chromatin assembly, indicating a broader role in epigenetic control.
• Localizes predominantly to the nucleus, consistent with its function as a transcription factor and chromatin modifier.
• Post‑translational modifications include phosphorylation and isopeptide bond formation, and the gene undergoes alternative splicing.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the full‑length human JDP2 protein (amino acids 1‑174), so the antibody may recognize multiple isoforms if alternative splicing products are present.
• For western blotting, consider optimizing primary antibody dilution and running appropriate positive controls (e.g., human or rat nuclear extracts) to confirm specific bands at ~19 kDa.
• In ELISA, validate the antibody using recombinant JDP2 protein or peptide and assess cross‑reactivity with other AP‑1 family members.
• Since human and rat reactivity is indicated, verify performance in the intended species before large‑scale studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research laboratories with comprehensive IVD raw-material supply, covering validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and specialized sourcing for rare targets. The JDP2 polyclonal antibody fits workflows exploring transcriptional regulation and AP‑1 signaling, and we can assist in procuring matched detection reagents and custom formulation services. Contact our team to discuss how we can streamline your raw‑material pipeline for AP‑1‑related projects.