Anti-JAKMIP2 Polyclonal Antibody for WB, ELISA - Q96AA8

Core Product Specifications and Parameters

Biological Background: JAKMIP2 Function and Localization

• JAKMIP2 (Janus kinase and microtubule-interacting protein 2) is also known as CTCL tumor antigen HD-CL-04, neuroendocrine long coiled-coil protein 1 (NECC1), and JAMIP2; alternative splicing produces multiple isoforms.
• The protein contains extensive coiled-coil regions, suggesting a role in mediating protein–protein interactions and potentially acting as a scaffolding factor.
• Subcellularly, JAKMIP2 localizes to the Golgi apparatus, indicating involvement in Golgi-related processes such as vesicular trafficking or protein sorting.
• Tissue expression is highest in the brain, with moderate levels in thymus, spleen, and lung, and lower levels in kidney, liver, and peripheral blood lymphocytes; it is also expressed in endocrine tissues like adrenal and pituitary glands, and in testis.
• The neuroendocrine expression pattern and coiled-coil architecture point to a possible function in secretory pathway regulation in neurons and endocrine cells.
• Identified through proteomics, JAKMIP2 is part of the reference proteome and has no currently assigned enzymatic activity.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 561-810, a region predicted to have coiled-coil structure; this may influence epitope accessibility in native versus denaturing conditions.
• For Western blot, expect a band near 95 kDa (predicted MW ~95 kDa; UniProt canonical mass 94,934 Da). Validate detection in relevant lysates (e.g., brain, testis) with appropriate loading controls.
• For ELISA, use the antibody as a capture or detection reagent; titrate and confirm specificity against recombinant JAKMIP2 or cell lysates from expressing tissues.
• Cross-reactivity with mouse and rat has been reported; consider sequence alignment of the immunogen region across species to anticipate possible signal variations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic manufacturers and researchers with high-quality IVD raw materials, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For targets like JAKMIP2, which is implicated in neuroendocrine and Golgi biology, CamelBio streamlines procurement so you can focus on developing robust assays and kits. Let us support your transition from concept to clinic with reliable, ready-to-use raw materials.