Anti-IP6K2 Polyclonal Antibody for IF/ICC, ELISA - Q9UHH9

Core Product Specifications and Parameters

Biological Background: IP6K2 Function and Localization

• IP6K2 (Inositol hexakisphosphate kinase 2), also known as PIUS (P(i)-uptake stimulator), IHPK2, or InsP6K2, is a member of the inositol phosphate kinase family.
• Catalyzes the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5), a key step in inositol phosphate metabolism.
• Localizes predominantly to the nucleus, indicating a role in nuclear signaling and gene regulation.
• Contains conserved ATP-binding and nucleotide-binding domains characteristic of kinase and transferase activities.
• Implicated in phospholipid metabolism and broader lipid signaling networks through its generation of high-energy inositol pyrophosphates.
• Subject to alternative splicing, potentially yielding multiple isoforms with distinct regulatory properties.
• Classified under keywords such as ATP-binding, Kinase, Lipid metabolism, Nucleotide-binding, Nucleus, Phospholipid metabolism, and Reference proteome.

Experimental Guidance and Technical Tips

• The immunogen covers the N‑terminal region (amino acids 1–180) of human IP6K2; consider that epitopes in this region may detect full‑length and certain N‑terminal isoforms.
• For IF/ICC, optimize fixation and permeabilization protocols to ensure antibody accessibility to the nuclear compartment.
• In ELISA applications, use recombinant IP6K2 protein as a standard and validate the assay in the relevant biological matrix.
• As a polyclonal antibody from rabbit, potential lot‑to‑lot variability may require titration and consistent controls for reproducible results.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw material procurement for manufacturers, laboratories, and research institutes by offering a comprehensive portfolio that includes validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. The IP6K2 polyclonal antibody supports inositol phosphate metabolism research and nuclear signaling studies, with CamelBio providing reliable supply, customized sourcing for rare targets, and technical support to bridge concept-to-clinic development needs.