Anti-IP6K1 Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - Q92551

Core Product Specifications and Parameters

Biological Background: IP6K1 Function and Localization

• IP6K1 (Inositol hexakisphosphate kinase 1) is also designated PiUS, IHPK1, and InsP6 kinase 1.
• The enzyme converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) and can also phosphorylate InsP5 to PP-InsP4, driving critical steps in inositol pyrophosphate synthesis.
• Encoded by the IP6K1 gene (GeneID: 9807) in humans, this ATP-binding kinase belongs to the inositol hexakisphosphate kinase family and is annotated as a transferase.
• IP6K1 localizes to both the cytoplasm and nucleus, supporting its involvement in multiple signaling compartments.
• Alternative splicing gives rise to multiple isoforms, and the protein is identified as a phosphoprotein in proteomics studies, suggesting dynamic regulation.
• With a calculated molecular weight of ~50 kDa, IP6K1 is widely expressed, though tissue-specific profiles are not detailed in this record.

Experimental Guidance and Technical Tips

• The immunogen spans the N‑terminal 1–220 amino acids of human IP6K1 (NP_695005.1); this region is likely conserved across human, mouse, and rat, aligning with the reported cross‑reactivity.
• For western blot (WB), expect a major band near 50 kDa; validate specificity by siRNA knockdown or comparison with recombinant protein in the relevant sample system.
• In immunohistochemistry (IHC‑P), antigen retrieval and detection conditions may need optimization due to the dual cytoplasmic/nuclear localization of IP6K1.
• ELISA applications should be tested using recombinant IP6K1 protein or cell lysates; consider a paired antibody format if developing a quantitative assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated B2B provider of raw materials for IVD manufacturers and research laboratories. This anti-IP6K1 rabbit monoclonal antibody supports studies in inositol phosphate metabolism and kinase signaling. Beyond individual antibodies, we offer validated antibody pairs, optimized monoclonal and polyclonal reagents, bulk ancillary materials, and can assist with sourcing rare‑target raw materials to streamline your assay development—from concept to clinic.