Anti-INPP1 Rabbit Polyclonal Antibody for WB and ELISA - P49441

Core Product Specifications and Parameters

Biological Background: INPP1 Function and Localization

• INPP1 encodes inositol polyphosphate 1-phosphatase, an enzyme involved in inositol phosphate metabolism.
• It is a Mg2+-dependent hydrolase that specifically removes the 1-position phosphate from inositol-1,4-bisphosphate and inositol-1,3,4-trisphosphate.
• The protein plays a central role in regulating cellular inositol phosphate second messenger pathways.
• Ubiquitously expressed, with highest levels detected in pancreas and kidney tissues.
• Sensitivity to lithium ions is a known biochemical feature, relevant to pharmacology and toxicity studies.
• Post-translational modifications include phosphorylation, as identified by proteomics approaches.
• Keywords associated with this protein include hydrolase, magnesium, metal-binding, and lithium sensitivity.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal region (residues 1–180) of human INPP1, which may recognize full-length and truncated forms if present.
• In Western blotting, a specific band around 44 kDa is anticipated; validate by comparing with known positive controls.
• For ELISA applications, consider optimizing coating and detection conditions using recombinant protein or peptide standards.
• Due to the polyclonal nature, if high specificity is required, affinity purification or pre-adsorption strategies may be employed.
• Expression is highest in pancreas and kidney; these tissues are suitable for positive control lysates.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio empowers diagnostic manufacturers and researchers with streamlined access to validated antibodies and ancillary reagents. For INPP1 research in inositol signaling and lithium pharmacology, we offer this polyclonal antibody alongside complementary products such as recombinant proteins, ELISA kits, and custom monoclonal antibody development. Our integrated supply chain supports your IVD development from concept to clinic, ensuring reliable bulk sourcing and technical consultation.