Anti-Inhibin beta A Rabbit Polyclonal Antibody for WB, ELISA - P08476

Core Product Specifications and Parameters

Biological Background: Inhibin beta A Function and Localization

• Inhibin beta A (INHBA), also known as Activin beta-A chain or Erythroid differentiation protein (EDF), is a secreted protein that forms homodimers (Activin A) or heterodimers (Inhibin A with alpha chain/INHA) to regulate diverse physiological processes.
• Activin A signals through type I (ACVR1B, ACVR1C) and type II receptors (ACVR2A, ACVR2B, BMPR2), phosphorylating SMAD2/3 to form a complex with SMAD4 that regulates gene expression (PubMed:10652306, PubMed:24018044). It also activates non-canonical pathways like p38 MAPK, ERK1/2, and JNK (PubMed:16440334). Related references: PMID:10652306, PMID:24018044, PMID:16440334
• Involved in embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation, and tissue fibrosis (PubMed:3194407, PubMed:16440334). Related references: PMID:3194407, PMID:16440334
• Inhibin A, the INHBA/INHA dimer, functions as a feedback regulator in the hypothalamic-pituitary-gonadal axis, inhibiting FSH secretion by antagonizing Activin A through betaglycan-mediated receptor sequestration.
• Promotes osteoblastic differentiation via the ACVRL1-SMAD1/5/9 pathway (PubMed:34948289) and can form non-signaling complexes with ACVR1 to inhibit BMP signaling (PubMed:26333933). Related references: PMID:34948289, PMID:26333933
• Subcellular localization: Secreted.
• Key keywords: Cleavage on pair of basic residues, disulfide bond, glycoprotein, growth factor, hormone, signal peptide, and proteomics identification.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-100) of human INHBA; expected band size in Western blot is ~47 kDa (pro-form). Validate in relevant cell or tissue lysates and consider potential detection of processed forms.
• For ELISA, the synthetic peptide immunogen provides suitability; use appropriate peptide or protein controls.
• The antibody cross-reacts with mouse, enabling studies in mouse models; validate its performance in your specific system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories a streamlined, one-stop sourcing solution for IVD raw materials. Our portfolio includes validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents. For targets such as Inhibin beta A—relevant to reproductive biology, stem cell research, and fibrosis—we can also assist with custom sourcing and technical consulting, helping bridge the gap from concept to clinic.