Anti-IL26 Rabbit Monoclonal Antibody for WB, ELISA - Q9NPH9

Core Product Specifications and Parameters

Biological Background: IL26 Function and Localization

• Interleukin-26 (IL26), also known as AK155, is a secreted cytokine belonging to the interleukin family.
• IL26 plays a role in local mucosal immunity and exhibits pro-inflammatory functions.
• It activates multiple signaling pathways including STAT1, STAT3, MAPK1/3 (ERK1/2), JUN, and AKT.
• IL26 induces the expression of SOCS3, TNF, IL8, and ICAM1, and promotes secretion of IL-8 and IL-10.
• It decreases proliferation of intestinal epithelial cells and its activity is inhibited by heparin.
• The protein is secreted and specifically expressed in HVS-transformed T-cells and colonic Th17 inflammatory T-cells, with elevated levels observed in serum of Crohn's disease patients.
• Uniprot keywords: Cytokine, Secreted, Signal, Reference proteome. Calculated molecular weight is approximately 19.8 kDa.

Experimental Guidance and Technical Tips

• For Western blotting, the predicted molecular weight is around 20 kDa; consider optimizing loading amounts and transfer conditions for your sample type.
• When performing ELISA, ensure the antibody is tested in a relevant matrix (e.g., culture supernatant or serum) and titrated for optimal signal-to-noise ratio.
• As the immunogen corresponds to amino acids 50–154, the antibody likely recognizes an epitope within this region; confirm reactivity with your target using a positive control such as stimulated T-cell lysates or recombinant protein.
• Validate specificity in the intended application system, as cross-reactivity data beyond human is not provided.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive portfolio of IVD raw materials and technical services, helping diagnostic developers accelerate from concept to clinic. For researchers focused on inflammatory bowel disease and mucosal immunity, CamelBio provides access to validated monoclonal antibodies like this anti-IL26 clone, along with bulk ancillary reagents and customized sourcing solutions. Partner with us to streamline your assay development with reliable, traceable raw materials.