Anti-IL23R Rabbit Monoclonal Antibody for FC, ELISA - Q5VWK5

Core Product Specifications and Parameters

Biological Background: IL23R Function and Localization

• Interleukin-23 receptor (IL23R, also known as PSORS7) is a type I transmembrane protein that pairs with IL12RB1 to form the functional receptor for interleukin-23 (IL-23).
• Upon IL-23 binding, the receptor complex activates the Jak-Stat signaling pathway, leading to stimulation of T cells, NK cells, and possibly some macrophage/myeloid populations.
• IL23R plays critical roles in both innate and adaptive immunity, contributing to acute responses to infection in peripheral tissues and linking inflammation to tumorigenesis.
• The receptor is implicated in autoimmune inflammatory diseases, consistent with its role in driving pro-inflammatory cytokine responses.
• IL23R localizes to the cell membrane as a multi-pass transmembrane protein.
• It is predominantly expressed on immune cells including monocytes, Th1, Th0, NK, and dendritic cells; isoform 1 is specifically found in NK cells.
• The protein undergoes alternative splicing and post-translational modifications including glycosylation and phosphorylation, which may modulate its activity and expression.

Experimental Guidance and Technical Tips

• As the immunogen spans the extracellular region (amino acids 124-353), this antibody likely recognizes an epitope accessible on the cell surface, making it suitable for flow cytometry applications without permeabilization.
• For flow cytometry, consider using IL23R-expressing immune cells (e.g., NK cells, Th1, Th0, or dendritic cells) as positive controls, but verify expression levels and antibody titration in your specific experimental system.
• The protein exhibits multiple isoforms and potential N-glycosylation, which may result in apparent molecular weights (41, 43, 72 kDa) that differ from the predicted 71.7 kDa; for western blot (if applied), validate in the relevant sample system.
• For ELISA applications, the antibody may be employed as a capture or detection reagent; optimization of coating concentration and matched detection pairs is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supplies this anti-IL23R rabbit monoclonal antibody to support research and diagnostic development in autoimmunity, inflammation, and oncology. As a one-stop IVD raw-material provider, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target sourcing to streamline your assay development from concept to clinic.