Anti-IL23R Monoclonal Antibody for FC - Q5VWK5

Core Product Specifications and Parameters

Biological Background: IL23R Function and Localization

• Interleukin-23 receptor (IL23R, also known as PSORS7) is a single-pass type I membrane protein encoded by the IL23R gene. It associates with IL12RB1 to form the functional IL-23 receptor complex.
• Upon binding of interleukin-23 (IL23), the receptor activates the Jak-Stat signaling cascade, leading to stimulation of T-cells, NK cells, and possibly certain macrophage/myeloid cells.
• IL23R plays a critical role in both innate and adaptive immunity, participating in acute responses to infection in peripheral tissues.
• Dysregulation of IL23R signaling is implicated in autoimmune inflammatory diseases and may contribute to tumorigenesis.
• The receptor localizes on the cell membrane, consistent with its function as a transmembrane signaling receptor.
• IL23R is expressed primarily in immune cells such as monocytes, Th1, Th0, NK cells, and dendritic cells; isoform 1 is specifically expressed in NK cells.
• The protein undergoes alternative splicing, producing multiple isoforms with calculated molecular weights around 41 kDa, 43 kDa, and 72 kDa; the canonical isoform is about 72 kDa.
• The receptor contains characteristic structural features including a signal peptide, extracellular immunoglobulin-like domains, a transmembrane helix, and intracellular signaling motifs, annotated under keywords such as glycoprotein, phosphoprotein, and alternative splicing.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 124–353 of human IL23R, which lies within the extracellular domain, making this antibody potentially suitable for live-cell surface staining in flow cytometry.
• Optimal antibody concentration should be titrated experimentally in the target cell system. Include appropriate isotype controls and perform Fc receptor blocking if necessary.
• Validate specificity using known IL23R-positive cell lines (e.g., NK cells, activated T cells) and a negative control line with undetectable IL23R expression.
• Since cross-reactivity is limited to human, confirm species specificity if used in models involving human xenografts or mixed species samples.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with streamlined access to validated IVD raw materials, including this anti-IL23R monoclonal antibody for immune-related research. Our comprehensive supply covers optimized monoclonal and polyclonal antibodies, validated antibody pairs, bulk ancillary reagents, and rare-target sourcing, enabling your projects from concept to clinic.