Anti-IL20RB Polyclonal Antibody for WB, ELISA - Q6UXL0

Core Product Specifications and Parameters

Biological Background: IL20RB Function and Localization

• IL20RB, also known as IL-20R2 or FNDC6, is the interleukin-20 receptor subunit beta. It is encoded by the IL20RB gene (alternatively spliced) and functions as a receptor subunit for cytokines IL19, IL20, and IL24.
• The protein forms heterodimers: IL20RA/IL20RB acts as a receptor for IL19, IL20, and IL24, while IL22RA1/IL20RB serves as a receptor for IL20 and IL24, mediating signaling involved in inflammatory and immune responses.
• IL20RB is a membrane protein with a signal peptide, extracellular fibronectin type III domains, a single transmembrane helix, and a cytoplasmic tail. The immunogen corresponds to a portion of the extracellular domain.
• The protein is widely expressed with highest levels in skin and testis, and is notably upregulated in psoriatic skin, consistent with its role in skin inflammation and innate immunity.
• Key post-translational modifications include glycosylation and disulfide bond formation. The receptor also features alternative splicing isoforms (as indicated by the 'Alternative splicing' keyword) and has been identified in proteomics studies.
• Its three-dimensional structure has been determined (PDB available), aiding in understanding ligand-receptor interactions and drug design targeting cytokine pathways.
• As a receptor for IL20 family cytokines, IL20RB is implicated in chronic inflammatory diseases, making it a target of interest for diagnostic and therapeutic development.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 48-177, which lies within the predicted extracellular region. This design may provide good accessibility to epitopes in native membrane contexts; however, validate staining in your specific tissue or cell type.
• This antibody is indicated for WB and ELISA by the manufacturer. For WB, a band near 35 kDa is expected. Consider optimizing antibody dilution and blocking conditions according to your sample system.
• Reported cross-reactivity includes human, mouse, and rat, suggesting possible utility in translational models. Confirm reactivity in species-specific assays as needed.
• As a polyclonal antibody, batch-to-batch consistency may vary; we recommend including appropriate controls (e.g., antigen competition) when establishing new protocols.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research groups with a comprehensive sourcing platform for IVD raw materials, including validated polyclonal antibodies like this anti-IL20RB antibody for cytokine receptor studies. Our supply chain ensures access to optimized antibodies, bulk ancillary reagents, and rare target materials, supporting seamless development from concept to clinic.