Anti-IL17RB Rabbit Polyclonal Antibody for WB & ELISA - Q9NRM6

Core Product Specifications and Parameters

Biological Background: IL17RB Function and Localization

• IL17RB, also known as Interleukin-17 receptor B, Cytokine receptor-like 4, IL-17 receptor homolog 1 (IL-17Rh1), and IL-17B receptor, is encoded by the IL17RB gene (CRL4, EVI27, IL17BR) and exhibits alternative splicing.
• It functions as a receptor for the pro-inflammatory cytokines IL17B and IL17E, potentially playing a role in controlling the growth and/or differentiation of hematopoietic cells.
• The protein is a transmembrane receptor localized primarily to the cell membrane, but a secreted form also exists.
• Post-translational modifications include glycosylation, as indicated by its glycoprotein keyword.
• Tissue expression is prominent in endocrine tissues, including fetal and adult liver, kidney, pancreas, testis, colon, brain, and small intestine; it is not detected in peripheral blood leukocytes or lymphoid organs.
• According to UniProt keywords, the protein features a signal peptide, a transmembrane helix, and undergoes alternative splicing, suggesting the existence of multiple isoforms.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 18–292) covers the extracellular domain of IL17RB; for Western blot, a band around 56 kDa is expected under reducing conditions.
• For ELISA applications, consider pairing this polyclonal antibody with a suitable capture or detection antibody, and validate reactivity against the relevant sample matrix.
• Cross-reactivity with mouse and rat has been observed; appropriate positive and negative controls from these species should be included to confirm specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, laboratories, and research institutes streamlined access to IVD raw materials, including validated antibody pairs, optimized polyclonal and monoclonal antibodies, as well as bulk ancillary reagents. This IL17RB antibody is part of our comprehensive immunology and cell signaling portfolio, supporting research and assay development in cytokine receptor biology. We also assist in sourcing rare-target raw materials, backed by our technical services and consulting expertise to accelerate your journey from concept to clinic.