Anti-IL17C Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - Q9P0M4

Core Product Specifications and Parameters

Biological Background: IL-17C Function and Localization

• Interleukin-17C (IL-17C), also known as cytokine CX2, is a secreted cytokine belonging to the IL-17 family.
• It plays a crucial role in innate immunity of the epithelium, responding to intestinal bacterial pathogens in an autocrine manner.
• IL-17C stimulates production of antibacterial peptides (e.g., S100A8, S100A9, REG3A, REG3G) and pro-inflammatory molecules via NF-kappa-B and MAPK pathways.
• Synergizes with IL-22, TNF, and IL-1B to enhance antibacterial peptide expression, such as DEFB2 from keratinocytes.
• Depending on the inflammatory context, IL-17C can maintain epithelial homeostasis or promote inflammatory phenotypes, potentially contributing to autoimmune disease susceptibility.
• Subcellular localization: Secreted
• Contains a signal peptide and disulfide bonds, typical of secreted cytokines.
• Molecular weight: 21.765 kDa (UniProt), consistent with the observed 22 kDa band.

Experimental Guidance and Technical Tips

• Consider using the antibody for Western blot (WB) detection of IL-17C, where a band around 22 kDa is expected.
• For immunofluorescence/immunocytochemistry (IF/ICC), ensure appropriate fixation and permeabilization to detect secreted cytokine.
• When performing ELISA, validate the assay with recombinant IL-17C standards.
• Cross-reactivity with mouse and rat IL-17C has been reported, enabling multi-species studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers reliable, high-quality IVD raw materials for immunoassay development, bridging the gap from concept to clinic. Alongside this anti-IL-17C polyclonal antibody, we provide comprehensive sourcing for validated antibody pairs, optimized monoclonal antibodies, and bulk ancillary reagents to support your epithelial immunity and inflammation research. Contact us for rare target raw-material procurement and tailored technical consultation.