Anti-IL13RA2 Polyclonal Antibody for WB, IF/ICC, IHC-P, ELISA - Q14627

Core Product Specifications and Parameters

Biological Background: IL13RA2 Function and Localization

• Interleukin-13 receptor subunit alpha-2 (IL13RA2), also known as interleukin-13-binding protein, is a cell surface receptor encoded by the IL13RA2 gene in humans.
• Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway, thereby modulating immune responses and inflammation. Related references: PMID:11861389 PMID:17030238
• Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1, ultimately leading to the production of TGFB1. Related references: PMID:16327802
• Localizes to the cell membrane as a single-pass type I membrane protein.
• Contains fibronectin type-III domains and belongs to the type I cytokine receptor family; annotated with keywords such as glycoprotein, disulfide bond, and transmembrane helix.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide corresponding to amino acids 50-150, located in the extracellular domain. This region may allow detection of both membrane-bound and soluble forms of IL13RA2.
• For Western blotting, expect a band around 44 kDa under reducing conditions; consider optimizing blocking and antibody dilution for your specific lysate type.
• Cross-reactivity with mouse and rat IL13RA2 is indicated; validate with appropriate positive and negative controls in your model system.
• This polyclonal antibody may be suitable for immunofluorescence/immunocytochemistry (IF/ICC), immunohistochemistry on paraffin-embedded sections (IHC-P), and ELISA applications as listed; each requires individual optimization.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. For studies targeting IL13RA2 and IL-13 signaling, we supply validated antibody pairs, optimized polyclonal and monoclonal antibodies, bulk ancillary reagents, and expert support in sourcing rare-target raw materials. Partner with us to streamline your development workflow from early-stage research to clinical application.