Anti-IGSF6 Rabbit Polyclonal Antibody for WB and ELISA - O95976

Core Product Specifications and Parameters

Biological Background: IGSF6 Function and Localization

• IGSF6 (Immunoglobulin superfamily member 6), also known as DORA, is a member of the immunoglobulin superfamily.
• The protein contains an immunoglobulin domain, a signal peptide, and a transmembrane helix, consistent with its localization to the cell membrane.
• IGSF6 is expressed predominantly in peripheral blood lymphocytes, spleen, and lymph node, with low levels in thymus, bone marrow, and fetal liver; it is absent from non-immune tissues.
• A disulfide bond is predicted within the immunoglobulin domain, contributing to structural stability.
• The unprocessed precursor has a calculated molecular weight of 27,013 Da; the mature protein after signal peptide cleavage is approximately 24.5 kDa.
• Classified as part of the reference proteome, IGSF6 has been identified in proteomics studies.

Experimental Guidance and Technical Tips

• For Western blotting, consider using membrane protein extraction protocols to enhance detection of IGSF6, which is localized to the cell membrane.
• Validate antibody specificity in human, mouse, or rat lymphocyte lysates, spleen, or lymph node tissues, where IGSF6 is known to be highly expressed.
• For ELISA, the polyclonal nature of the antibody may provide robust signal, but appropriate blocking and control experiments are recommended to confirm specificity.
• The immunogen covers the full-length protein (aa 1-241), which may allow detection of multiple epitopes in both native and denatured conformations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a comprehensive partner for IVD raw materials, offering validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents to support your diagnostic and research programs. This anti-IGSF6 antibody targets a membrane protein expressed in immune tissues, making it a relevant tool for immunology studies and assay development. With end-to-end sourcing capabilities, CamelBio can also help you secure rare-target materials to advance your projects from concept to clinic.