Anti-IGFBP7 Rabbit Polyclonal Antibody for WB, ELISA - Q16270

Core Product Specifications and Parameters

Biological Background: IGFBP7 Function and Localization

• IGFBP7 (Insulin-like growth factor-binding protein 7) is a secreted protein belonging to the IGFBP family, also designated as IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, prostacyclin-stimulating factor, or tumor-derived adhesion factor (TAF).
• Binds IGF1 and IGF2 with relatively low affinity, modulating insulin-like growth factor signaling.
• Stimulates the production of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation (PGI2-stimulating factor activity).
• Promotes cell adhesion, functioning as a tumor-derived adhesion factor (TAF).
• Serves as a ligand for CD93, contributing to angiogenesis regulation.
  Related references:
  PMID:38218180
• Subcellularly, IGFBP7 is secreted into the extracellular space.
• Structural features include an immunoglobulin domain, disulfide bonds, glycosylation, and phosphorylation sites.
• The protein undergoes alternative splicing and RNA editing, generating multiple isoforms.

Experimental Guidance and Technical Tips

• For Western blot detection, the expected molecular weight is approximately 29 kDa; note that glycosylation may result in a higher apparent molecular weight.
• Due to the secreted nature of IGFBP7, consider enriching or using conditioned media to improve detection sensitivity.
• In ELISA applications, the antibody may be used as a detection reagent; pairing with a capture antibody against a non-overlapping epitope is recommended for sandwich assays.
• Cross-reacts with mouse and rat IGFBP7; validate in sample matrices relevant to your experimental model.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. For IGFBP7, a key player in cell adhesion, angiogenesis, and cancer biology, we offer validated polyclonal antibodies and can source matched antibody pairs, bulk ancillary reagents, and rare-target raw materials to support your assay development needs.