Anti-IGF2BP3 Polyclonal Antibody for WB, ELISA - O00425

Core Product Specifications and Parameters

Biological Background: IGF2BP3 Function and Localization

• Also known as IMP3, KOC, and VICKZ3; a member of the insulin-like growth factor 2 mRNA-binding protein family.
• Functions as an RNA-binding protein that recruits target transcripts into cytoplasmic mRNPs, shielding mRNAs from degradation and modulating translation.
• Preferentially binds to N6-methyladenosine (m6A)-modified mRNAs, enhancing their stability; for example, it binds to the coding region instability determinant (CRD) of MYC mRNA, increasing its stability in an m6A-dependent manner. Related references: PMID:29476152
• Binds to the 3'-UTR of CD44 and the 5'-UTR of IGF2, influencing cell adhesion, invadopodia formation, and growth factor regulation.
• Subcellularly localized to the nucleus, cytoplasm, P-bodies, and stress granules, reflecting its roles in mRNA transport and stress responses.
• Highly expressed during fetal development and in various cancers (e.g., cervix adenocarcinoma, pancreatic carcinoma), serving as an oncofetal protein and diagnostic marker.
• Post-translationally modified by phosphorylation and ubiquitination (isopeptide bond), with alternative splicing producing multiple isoforms.

Experimental Guidance and Technical Tips

• The antibody is raised against the N-terminal region (aa 1-200) of human IGF2BP3; consider validating specificity in your target sample system, especially if truncated isoforms are relevant.
• For Western blotting, expect a primary band near 64 kDa; additional bands may arise from modifications or isoforms. Titrate the antibody for optimal signal.
• Indicated cross-reactivity with mouse and rat allows for potential use in rodent models; always verify performance in the desired tissue or cell line.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with streamlined access to validated antibody pairs, monoclonal/polyclonal antibodies, and bulk ancillary reagents for IVD development. This IGF2BP3 antibody supports cancer biomarker research and RNA-binding protein studies; our team can also assist in sourcing matched detection reagents or custom antibodies for rare targets. From concept to clinic, CamelBio is your reliable partner for raw-material procurement and technical consulting.