Anti-IFNGR2 Polyclonal Antibody for WB, ELISA - P38484

Core Product Specifications and Parameters

Biological Background: IFNGR2 Function and Localization

• IFNGR2, also known as interferon gamma receptor 2, AF-1, or IFN-gamma receptor beta-chain, is the signal-transducing subunit of the interferon gamma receptor.
• It forms a functional receptor with IFNGR1; ligand binding triggers activation of the JAK/STAT signaling pathway. Related references: PMID:7615558 PMID:7673114 PMID:8124716 PMID:15356148
• IFNGR2 is essential for signal transduction, whereas IFNGR1 is primarily responsible for ligand binding. Related references: PMID:7673114
• Subcellularly, IFNGR2 is localized to the cell membrane, cytoplasmic vesicle membrane, Golgi apparatus membrane, endoplasmic reticulum membrane, and cytoplasm.
• It is detected in T-cells at the protein level.
• The protein is glycosylated, contains disulfide bonds, and features a signal peptide and a transmembrane helix.
• Clinically, mutations in IFNGR2 are associated with immunodeficiency 28 (IMD28), a form of Mendelian susceptibility to mycobacterial disease.

Experimental Guidance and Technical Tips

• For Western blotting, use denaturing and reducing conditions; the predicted molecular weight is 38 kDa.
• For ELISA, the antibody may be used as a capture or detection reagent; validate optimal concentrations in your assay system.
• The immunogen corresponds to a region spanning the extracellular-transmembrane-cytoplasmic junction; reactivity may occur against both full-length and truncated forms.
• Confirm antibody specificity using IFNGR2 knockdown or knockout cell lysates.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop sourcing partner for IVD raw materials, technical services, and consulting—from concept to clinic. We supply validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target raw materials for immunology and interferon signaling research. Contact CamelBio to accelerate your diagnostic assay development with reliable, high-quality raw materials.