Anti-Human GP6/GPVI Monoclonal Antibody for Flow Cytometry - Q9HCN6

Core Product Specifications and Parameters

Biological Background: GP6/GPVI Function and Localization

• Platelet glycoprotein VI (GP6), also referred to as GPVI, is a transmembrane receptor of the immunoglobulin superfamily.
• GPVI functions as a key collagen receptor on platelets, initiating collagen-induced platelet adhesion and activation.
• It promotes platelet procoagulant activity, leading to thrombin and fibrin formation, a process implicated in arterial and venous thrombosis.
• Signal transduction involves the FcR gamma-chain, Src kinases (FYN or LYN), SYK, the adapter protein LAT, and activation of PLCG2.
• Expression is restricted to megakaryocytes and platelets, reflecting its specialized role in hemostasis.
• The protein resides at the cell membrane and undergoes alternative splicing; several disease-associated variants have been reported.
• Structural motifs include an immunoglobulin domain, disulfide bonds, and N-linked glycosylation, with a molecular weight of approximately 37 kDa.

Experimental Guidance and Technical Tips

• The conjugated fluorophore enables direct detection without secondary antibody, streamlining flow cytometry workflows.
• Based on the immunogen design (recombinant protein covering amino acids 21–267, the extracellular region), this antibody is expected to recognize native GPVI on the surface of live platelets.
• For optimal staining, consider using platelet-rich plasma or whole blood samples; fixation and permeabilization may not be required for surface staining.
• Since the antibody is specific for human GPVI, cross-reactivity with other species is not expected; validate in human sample systems.
• Titrate the antibody to determine the optimal concentration for your specific experimental conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, from concept to clinic. For thrombosis and hemostasis research, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and assistance in sourcing rare targets such as GPVI. Empower your diagnostic development with reliable, high-quality reagents backed by CamelBio's supply-chain expertise.